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Related Experiment Videos

Evidence for early lower urinary tract dysfunction in clinically silent multiple sclerosis.

B L Bemelmans1, O R Hommes, P E Van Kerrebroeck

  • 1Department of Urology, University Hospital Nijmegen, The Netherlands.

The Journal of Urology
|June 1, 1991
PubMed
Summary

Multiple sclerosis (MS) frequently affects the urinary system early, even in asymptomatic patients. Early neurourodynamic testing is crucial for diagnosing lower urinary tract dysfunction in MS patients.

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Area of Science:

  • Neurology
  • Urology
  • Neuroscience

Background:

  • Late-onset micturition complaints in multiple sclerosis (MS) are well-documented.
  • Limited research exists on early-stage MS patients without urinary symptoms.
  • Understanding early lower urinary tract (LUT) dysfunction in MS is critical.

Purpose of the Study:

  • To investigate neurourodynamic abnormalities in early MS patients, with and without micturition complaints.
  • To assess the clinical implications of early neurourodynamic testing in MS.
  • To determine if LUT dysfunction is an early manifestation of MS.

Main Methods:

  • Prospective study of 40 definite MS patients (mean disease duration 5 years).
  • Combined urodynamic investigations (cystometry, pressure-flow study) with neuro-urophysiological measurements (cortical evoked potentials, sacral reflex latencies).

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  • Patients categorized into those with (13) and without (27) micturition complaints.

    • Main Results:

    • Neurourodynamic abnormalities were detected in 88% (35/40) of MS patients.
    • Lower urinary tract dysfunction was evident even in patients without micturition complaints.
    • Abnormalities identified in all symptomatic and half of asymptomatic patients informed follow-up and treatment decisions.

    Conclusions:

    • Multiple sclerosis affects the lower urinary tract early in its disease course.
    • Neurourodynamic testing is valuable for initial evaluation of urinary function in MS patients.
    • Early detection of LUT dysfunction can guide management and intervention in MS.