Association between a serotonin transporter length polymorphism and primary insomnia
Related Experiment Video
Updated: Jun 14, 2026

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
Published on: April 26, 2024
Michael Deuschle1, Michael Schredl, Claudia Schilling
1Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Mannheim, Germany. michael.deuschle@zi-mannheim.de
Study Objective:
To test the hypothesis that a 44-base-pair insertion/deletion polymorphism in the 5' regulatory region of the serotonin transporter gene (5-HTTLPR) is associated with primary insomnia.
Design:
Association study.
Setting:
Sleep laboratory at the Central Institute of Mental Health, Mannheim, Germany.
Patients:
157 patients with primary insomnia and 827 healthy controls.
Interventions:
N/A.
Measurement And Results:
We found the short (s-) allele of the 5-HTTLPR to be significantly more frequent in patients suffering from insomnia than in control individuals (47.1% vs. 39.9%: OR = 1.34).
Conclusions:
This finding contributes to the understanding of the pathophysiology of primary insomnia and suggests a biological basis between the prevalent comorbidity of primary insomnia and other psychiatric disorders.
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