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T3098C and T53C mutations of HBV genotype C is associated with HBV infection progress

Su-Zhen Jiang1, Zhi-Yong Gao, Tong Li

  • 1Department of Microbiology, Peking University Health Scienice Center, Beijing 100191, China.

Biomedical and Environmental Sciences : BES
|March 27, 2010
PubMed

Insights

Specific mutations in the preS region of Hepatitis B Virus (HBV) genotype C are linked to disease progression. These findings highlight potential biomarkers for monitoring chronic HBV infection advancement.

Area of Science:

  • Hepatology
  • Virology
  • Genetics

Background:

  • Chronic Hepatitis B Virus (HBV) infection is a global health concern.
  • Genotype C HBV is prevalent in East Asia and associated with distinct disease trajectories.
  • The preS region of the HBV genome plays a role in viral replication and pathogenesis.

Purpose of the Study:

  • To investigate the association between mutations in the preS region of HBV genotype C and the progression of liver disease.
  • To identify specific preS mutations that correlate with different stages of chronic HBV infection, including asymptomatic carriers, chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma.

Main Methods:

  • A cohort of 93 Chinese patients with chronic HBV genotype C infection was analyzed.
  • Patients were categorized into four groups: asymptomatic carriers (ASC), chronic hepatitis B (CHB), liver cirrhosis (LC), and hepatocellular carcinoma (HCC).
  • HBV DNA levels, HBeAg, ALT, AST were measured, and the HBV preS region was analyzed using PCR direct sequencing.

Main Results:

  • The prevalence of preS T3098C and T53C mutations was significantly higher in patients with liver cirrhosis (LC) and hepatocellular carcinoma (HCC) compared to asymptomatic carriers (ASC) and chronic hepatitis B (CHB) patients.
  • The rate of T3098C mutation increased progressively from ASC (0%) to CHB (3.85%), LC (9.09%), and HCC (30.77%).
  • Similarly, the T53C mutation rate was higher in LC (40.91%) and HCC (42.31%) patients compared to ASC (12.50%) and CHB (3.85%) patients.

Conclusions:

  • The frequency of genotype C HBV preS T3098C and T53C mutations is significantly associated with the progression of hepatitis B infection.
  • These preS mutations may serve as potential biomarkers for predicting disease advancement in chronic HBV genotype C infection.
Abstract

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