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Related Concept Videos

Asymmetric Lipid Bilayer01:35

Asymmetric Lipid Bilayer

Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...
Structure of Lipids03:38

Structure of Lipids

Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic birds and...
Structure of Lipids03:38

Structure of Lipids

Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic birds and...
Structure of Lipids03:38

Structure of Lipids

Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic birds and...
Membrane Fluidity01:26

Membrane Fluidity

Membrane fluidity is explained by the fluid mosaic model of the cell membrane, which describes the plasma membrane structure as a mosaic of components—including phospholipids, cholesterol, proteins, and carbohydrates—that gives the membrane a fluid character.
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is a relatively...
Membrane Fluidity01:23

Membrane Fluidity

Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.Fatty acids tails of phospholipids can be either saturated or...

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Updated: Jun 14, 2026

Realistic Membrane Modeling Using Complex Lipid Mixtures in Simulation Studies
07:31

Realistic Membrane Modeling Using Complex Lipid Mixtures in Simulation Studies

Published on: September 1, 2023

Structural aspects of lipid monolayers: computer simulation analyses.

Philip Shushkov1, Stanislav Tzvetanov, Maria Velinova

  • 1Laboratory of Quantum and Computational Chemistry, Department of Physical Chemistry, Faculty of Chemistry, University of Sofia, 1 James Bourchier Avenue, 1164 Sofia, Bulgaria.

Langmuir : the ACS Journal of Surfaces and Colloids
|March 27, 2010
PubMed
Summary
This summary is machine-generated.

Molecular dynamics simulations reveal how dipalmitoylphosphatidylcholine (DPPC) and dicaprin lipids organize at the air/water interface. These findings explain lipid diffusion and dielectric properties based on molecular packing.

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Last Updated: Jun 14, 2026

Realistic Membrane Modeling Using Complex Lipid Mixtures in Simulation Studies
07:31

Realistic Membrane Modeling Using Complex Lipid Mixtures in Simulation Studies

Published on: September 1, 2023

Atomic Force Microscopy Imaging and Force Spectroscopy of Supported Lipid Bilayers
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Atomic Force Microscopy Imaging and Force Spectroscopy of Supported Lipid Bilayers

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Automated Lipid Bilayer Membrane Formation Using a Polydimethylsiloxane Thin Film
08:23

Automated Lipid Bilayer Membrane Formation Using a Polydimethylsiloxane Thin Film

Published on: July 10, 2016

Area of Science:

  • Biophysics
  • Surface Chemistry
  • Computational Chemistry

Background:

  • Lipid monolayers at interfaces are crucial for biological systems and nanotechnology.
  • Understanding their organization and dynamics is key to controlling interfacial properties.

Purpose of the Study:

  • To investigate the molecular organization and dynamics of dipalmitoylphosphatidylcholine (DPPC) and dicaprin lipid monolayers at the air/water interface.
  • To correlate structural features with interfacial water behavior and lipid diffusion.

Main Methods:

  • Extensive molecular dynamics simulations at room temperature.
  • Analysis of density distributions, Voronoi tessellation, and radial distribution functions.
  • Calculation of diffusion coefficients for lipid components and interfacial water.

Main Results:

  • Detailed density profiles of lipid head/tail groups and interfacial water were determined.
  • Packing patterns and cluster sizes were analyzed across different molecular areas.
  • Lipid diffusion coefficients were correlated with structural arrangements and interfacial water interactions.

Conclusions:

  • The study provides insights into the structural basis for changes in monolayer dielectric properties with molecular area.
  • Identified limiting factors for both lateral and normal lipid diffusion.
  • Relates simulation findings to experimental data on lipid monolayers.