Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Specialized Characteristics of Cardiac Muscles01:27

Specialized Characteristics of Cardiac Muscles

The primary role of cardiac muscles is to propel blood throughout the cardiovascular system. The cardiac muscle cells, or cardiomyocytes, exhibit specialized characteristics that allow them to perform this function.
Cardiac muscle cells are smaller than skeletal muscles, averaging 10–20 mm in diameter and 50–100 mm in length. However, they have large energy demands for continuous contraction and relaxation. This energy is almost exclusively derived from aerobic metabolism of energy reserves in...
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Developing an evidence base to inform retirement home policy development using an equity and diversity lens: a mixed methods study protocol.

BMC geriatrics·2025
Same author

Heart transplantation and biomarkers: a review about their usefulness in clinical practice.

Frontiers in cardiovascular medicine·2024
Same author

Passive leg-lifting in heart failure patients predicts exercise-induced rise in left ventricular filling pressures.

Clinical research in cardiology : official journal of the German Cardiac Society·2019
Same author

A Paleolithic-type diet results in iodine deficiency: a 2-year randomized trial in postmenopausal obese women.

European journal of clinical nutrition·2017
Same author

Arterial calcification: A new perspective?

International journal of cardiology·2016
Same author

Gender and age effects on risk factor-based prediction of coronary artery calcium in symptomatic patients: A Euro-CCAD study.

Atherosclerosis·2016

Related Experiment Video

Updated: Jun 14, 2026

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples
14:39

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples

Published on: April 21, 2014

Profound cardiac conduction delay predicts mortality in myotonic dystrophy type 1.

S Mörner1, P Lindqvist, C Mellberg

  • 1Department of Cardiology, Heart Center, Umeå University Hospital, Umeå, Sweden. stellan.morner@medicin.umu.se

Journal of Internal Medicine
|March 27, 2010
PubMed
Summary

Cardiovascular issues in myotonic dystrophy type 1 (DM1) patients can predict survival. Early cardiac assessment may help prevent mortality in DM1 individuals.

More Related Videos

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
09:36

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia

Published on: December 22, 2023

Modeling Myotonic Dystrophy 1 in C2C12 Myoblast Cells
09:39

Modeling Myotonic Dystrophy 1 in C2C12 Myoblast Cells

Published on: July 29, 2016

Related Experiment Videos

Last Updated: Jun 14, 2026

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples
14:39

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples

Published on: April 21, 2014

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
09:36

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia

Published on: December 22, 2023

Modeling Myotonic Dystrophy 1 in C2C12 Myoblast Cells
09:39

Modeling Myotonic Dystrophy 1 in C2C12 Myoblast Cells

Published on: July 29, 2016

Area of Science:

  • Cardiology
  • Neuromuscular Disorders

Background:

  • Myotonic dystrophy type 1 (DM1) primarily affects the musculoskeletal system.
  • Early mortality in DM1 is often linked to respiratory issues and potential cardiovascular complications.

Purpose of the Study:

  • To identify cardiovascular disturbances that may predict survival in DM1 patients.
  • To assess the long-term prognostic value of cardiac assessments in DM1.

Main Methods:

  • 30 DM1 patients and 29 controls underwent electrocardiography (ECG) and echocardiography.
  • A subgroup of DM1 patients was re-evaluated after a 17-year follow-up period.
  • Analysis focused on ECG parameters (QRS duration, PR interval) and echocardiographic measurements (left ventricular size, fractional shortening).

Main Results:

  • DM1 patients showed slightly enlarged left ventricular end-systolic diameter and reduced fractional shortening compared to controls.
  • Nine DM1 patients had first-degree heart block, and 15 had a QRS duration >90 ms.
  • The sum of QRS duration and PR interval was the best predictor of mortality (AUC 85%, sensitivity 70%, specificity 84%).

Conclusions:

  • Subtle cardiac dysfunction in DM1 patients can lead to serious complications and increased mortality.
  • Regular, detailed cardiac assessments (electrical and mechanical) are crucial for DM1 patients.
  • Early intervention based on cardiac assessment may improve survival rates in DM1.