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Effects of early enteral feeding on fecal elastase 1 and plasma secretin

Noritsugu Kaneko1, Ken Hisata, Hiromichi Shoji

  • 1Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan.

Pediatrics International : Official Journal of the Japan Pediatric Society
|March 27, 2010
PubMed

Insights

Extremely early enteral feeding significantly enhanced pancreatic exocrine function and secretin secretion in very low-birthweight infants. This early nutrition supports gut development in vulnerable newborns.

Area of Science:

  • Neonatalogy
  • Pediatric Gastroenterology
  • Nutritional Science

Background:

  • Enteral feeding promotes gut hormone secretion and pancreatic exocrine function.
  • Investigating the impact of extremely early enteral feeding on very low-birthweight (VLBW) infants is crucial for their development.

Purpose of the Study:

  • To examine the effects of extremely early enteral feedings on the development of pancreatic exocrine function and secretin secretion in VLBW infants.

Main Methods:

  • Measured fecal elastase 1 and plasma secretin in VLBW infants receiving extremely early enteral feeding (within 24h) and control infants.
  • Assessed concentrations at four time points during the first 28 days of life.

Main Results:

  • Fecal elastase 1 levels were significantly higher in the early feeding group at 7 and 14 days.
  • Plasma secretin levels were significantly higher in the early feeding group at 14 days.
  • Both groups showed increased elastase 1 over time, but early feeding accelerated this development.

Conclusions:

  • Extremely early enteral feeding appears to play a vital role in developing pancreatic exocrine function.
  • Early nutrition may enhance secretin secretion in VLBW infants during the early neonatal period.
Abstract

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