Is it the patient or the IVF? Beckwith-Wiedemann syndrome in both spontaneous and assisted reproductive conceptions
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Updated: Jun 14, 2026

Human Egg Maturity Assessment and Its Clinical Application
Published on: August 19, 2019
Estil Y Strawn1, David Bick, Amy Swanson
1Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI 53226, USA. rwutsche@mcw.edu
Objective:
To describe two children diagnosed with Beckwith-Wiedemann Syndrome (BWS) arising from a spontaneous conception and an assisted reproductive technology (ART) cycle from one patient with a long-standing history of subfertility.
Design:
Case report.
Setting:
Academic medical center.
Patient(S):
Two children with the morphologic features of BWS as a result of a spontaneous conception and an ART cycle from the same patient.
Intervention(S):
Assisted reproductive technology.
Main Outcome Measure(S):
Neonatal and pediatric morphologic evaluation by geneticists.
Result(S):
Two children with the morphologic features consistent with the criteria for the diagnosis of BWS.
Conclusion(S):
Patients with subfertility may be carriers for genetic disorders that can be passed to a child with or without the use of assisted reproductive technologies (ART). The use of ART may bypass natural selection mechanisms.
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