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Late preterm birth and risk of developing asthma
Karon Abe1, Carrie K Shapiro-Mendoza, Laura R Hall
1Maternal and Infant Branch, Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341-3717, USA. kabe@cdc.gov
The Journal of Pediatrics
|March 27, 2010
Summary
Late preterm birth was not linked to a higher risk of childhood asthma. This study found no significant association between being born late preterm and later asthma diagnosis.
Area of Science:
- Pediatrics
- Epidemiology
- Respiratory Medicine
Background:
- Asthma is a common chronic respiratory disease in children.
- Premature birth, particularly late preterm birth, is a potential risk factor for adverse health outcomes.
- The relationship between late preterm birth and childhood asthma requires further investigation.
Purpose of the Study:
- To investigate the association between late preterm birth and the risk of physician-diagnosed asthma in early childhood.
- To determine if gestational age at birth influences asthma development.
Main Methods:
- Retrospective cohort study utilizing the Third National Health and Nutrition Examination Survey (NHANES) and linked natality files.
- Inclusion of children aged 2-83 months from singleton births, categorized as late preterm or term.
- Survival analysis and Cox proportional hazard regression were used to model time to asthma diagnosis, adjusting for multiple covariates.
Main Results:
- Physician-diagnosed asthma showed a modest, but not statistically significant, association with late preterm birth (Hazard Ratio: 1.3, 95% CI: 0.8-2.0, P=.30).
- The adjusted analysis did not reveal a significant link between late preterm birth and asthma risk.
Conclusions:
- Late preterm birth is not significantly associated with an increased risk of physician-diagnosed asthma in early childhood.
- These findings suggest that other factors may play a more significant role in childhood asthma development.
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