Related Experiment Video
Updated: Jun 14, 2026

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation
Published on: September 4, 2017
A graphic user interface toolkit for specification, report and comparison of dose-response relations and treatment
Fan-Chi Su1, Panayiotis Mavroidis, Chengyu Shi
1Department of Therapeutic Radiology, Yale-New Haven Hospital, 20 York street, New Haven, CT 06510, USA. fan-chi.su@ynhh.org
Abstract:
A toolkit (BEUDcal) has been developed for evaluating the effectiveness and for predicting the outcome of treatment plans by calculating the biologically effective uniform dose (BEUD) and complication-free tumor control probability. The input for the BEUDcal is the differential dose-volume histograms of organs exported from the treatment planning system. A clinical database is built for the dose-response parameters of different tumors and normal tissues. Dose-response probabilities of all the examined organs are illustrated together with the corresponding BEUDs and the P(+) values. Furthermore, BEUDcal is able to generate a report that simultaneously presents the radiobiological evaluation together with the physical dose indices, showing the complementary relation between the physical and radiobiological treatment plan analysis performed by BEUDcal. Comparisons between treatment plans for helical tomotherapy and multileaf collimator-based intensity modulated radiotherapy of a lung patient were demonstrated to show the versatility of BEUDcal in the assessment and report of dose-response relations.
Related Concept Videos
Dose Response Curve: Conventional Versus Nonmonotonic
Dose-Response Relationship: Overview
Dosage Regimens: Designs and Approaches
Dosage Regimen Designs: Nomograms and Tabulations
Dose-Response Relationship: Potency and Efficacy
Dosage Regimen: Individualization
