Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hormonal Regulation

Hormonal Regulation

The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.

Hypertension II: Pathophysiology

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...

Pathophysiology of Diabetes

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...

Acute Pancreatitis II: Pathophysiology

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...

Type II Diabetes II: Pathophysiology

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Aspirin-related hemorrhagic complications in pregnancy: a nationwide French cohort study (ASPREG).

Scientific reports·2026

Same author

Posttraumatic stress disorder after second-trimester medical termination of pregnancy.

American journal of obstetrics and gynecology·2026

Same author

sFlt-1/PlGF ratio use does not reduce hospitalisation duration in suspected preeclampsia: the PRECOG study, a multicentre randomised trial.

Scientific reports·2025

Same author

Non-invasive cell-free DNA prenatal screening for trisomy 21 as part of primary screening strategy in twin pregnancy.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2023

Same author

[Simulation training for French obstetrics and gynecology residents: A national survey in 2022].

Gynecologie, obstetrique, fertilite & senologie·2023

Same author

Recurrence of hypertensive disorders of pregnancy: results from a nationwide prospective cohort study (CONCEPTION).

BJOG : an international journal of obstetrics and gynaecology·2023

Search research articles

Related Experiment Video

Updated: Jun 14, 2026

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Published on: January 26, 2024

[Pathophysiology of preeclampsia].

V Tsatsaris¹, T Fournier, N Winer

¹Maternité Port-Royal, hôpital Cochin-Saint-Vincent-de-Paul, AP-HP, 123, boulevard de Port-Royal, 75014 Paris, France. vassilis.tsatsaris@cch.aphp.fr

Annales Francaises D'Anesthesie Et De Reanimation

|March 27, 2010

Summary

Preeclampsia, a pregnancy complication, stems from placental dysfunction leading to maternal endothelial injury. Understanding its pathophysiology offers hope for new screening and therapies for this condition.

More Related Videos

A Plate-based Cytotoxicity Assay for the Assessment of Rat Placental Natural Killer Cell Cytolytic Function

A Plate-based Cytotoxicity Assay for the Assessment of Rat Placental Natural Killer Cell Cytolytic Function

Published on: June 2, 2019

Related Experiment Videos

Last Updated: Jun 14, 2026

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Published on: January 26, 2024

A Plate-based Cytotoxicity Assay for the Assessment of Rat Placental Natural Killer Cell Cytolytic Function

A Plate-based Cytotoxicity Assay for the Assessment of Rat Placental Natural Killer Cell Cytolytic Function

Published on: June 2, 2019

Area of Science:

Obstetrics and Gynecology
Maternal-Fetal Medicine
Pathophysiology

Context:

Preeclampsia is a serious pregnancy complication specific to humans, typically emerging in the second trimester.
It involves placental dysfunction that releases substances into maternal circulation, potentially injuring the endothelium.
This leads to characteristic symptoms like maternal hypertension, glomerulonephritis, and increased vascular permeability.

Purpose:

To elucidate the pathophysiological mechanisms underlying preeclampsia.
To detail the impaired uterine vascular remodeling characteristic of preeclampsia.
To explain placental and endothelial dysfunctions contributing to preeclampsia.

Summary:

Preeclampsia arises from placental dysfunction, releasing vasoactive substances that activate or injure maternal endothelium.
This endothelial dysfunction results in systemic hypertension, kidney damage (glomerulonephritis), and increased vascular permeability.
The chapter focuses on impaired uterine vascular remodeling and placental/endothelial issues in preeclampsia pathophysiology.

Impact:

Advances understanding of preeclampsia's complex pathophysiology.
Provides a foundation for developing novel screening tools for preeclampsia.
Informs the search for potential therapeutic strategies to manage preeclampsia.