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Published on: March 27, 2026
Comparative clinical study of two tooth bleaching protocols with 6% hydrogen peroxide
Jesús Oteo Calatayud1, Paloma Mateos de la Varga, Carlos Oteo Calatayud
1Department of Conservative Dentistry, School of Dentistry, University Complutense of Madrid, 28040 Madrid, Spain.
International Journal of Dentistry
|March 27, 2010
Summary
This study found that a 6% hydrogen peroxide paint-on gel effectively whitens teeth. Both in-office and at-home applications by patients yielded significant clinical efficacy in tooth bleaching.
Area of Science:
- Dentistry
- Cosmetic Dentistry
- Dental Materials
Background:
- Over-the-counter (OTC) tooth whitening products are widely used.
- The efficacy of different application methods for 6% hydrogen peroxide paint-on gels requires further clinical evaluation.
Purpose of the Study:
- To compare the clinical efficacy of two tooth bleaching protocols using a 6% hydrogen peroxide paint-on gel.
- To assess efficacy after 1 and 2 weeks of treatment.
Main Methods:
- A randomized, single-blind, split-mouth clinical trial involving 16 patients.
- One hemi-arch received in-office application (Group I), while the other received daily at-home application by patients (Group II).
- Efficacy was measured using the Vita Classical shade guide at baseline, 1 week, and 2 weeks.
Main Results:
- Significant shade value improvements were observed in both the in-office and at-home treatment groups (P < .05).
- No statistically significant difference in tooth shade was found between the two application methods at the end of the treatment period.
Conclusions:
- The 6% hydrogen peroxide paint-on gel demonstrates significant clinical efficacy for tooth bleaching.
- Both clinician-applied and patient-applied methods achieve comparable and effective tooth whitening results.
