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Related Experiment Video

Updated: Jun 14, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

Gene polymorphisms in chronic periodontitis.

Marja L Laine¹, Bruno G Loos, W Crielaard

¹Department of Oral Microbiology, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije University, 1081 BT Amsterdam, The Netherlands.

International Journal of Dentistry

|March 27, 2010

Summary

Genetic variations in genes like IL1 and IL6 may influence chronic periodontitis (CP) susceptibility. However, current studies on gene polymorphisms require larger sample sizes and better controls for conclusive evidence.

Related Experiment Videos

Last Updated: Jun 14, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

Area of Science:

Genetics
Periodontology
Immunology

Background:

Chronic periodontitis (CP) is a prevalent inflammatory condition affecting periodontal tissues.
Genetic factors are increasingly recognized for their role in CP susceptibility and progression.

Purpose of the Study:

To review existing literature on gene polymorphisms associated with chronic periodontitis susceptibility.
To identify specific genes and their polymorphisms potentially linked to CP risk.

Main Methods:

Comprehensive literature search using keywords: periodontitis, periodontal disease, genes, mutation, polymorphism.
Review of candidate gene polymorphism studies with case-control designs and reported genotype frequencies in CP patients.

Main Results:

Evidence suggests polymorphisms in IL1, IL6, IL10, vitamin D receptor, and CD14 genes may be associated with CP in specific populations.
Significant variability in rare allele carriage rates and underpowered studies were noted.
Most studies did not adequately control for other known risk factors for CP.

Conclusions:

Gene polymorphisms in IL1, IL6, IL10, VDR, and CD14 show potential links to CP susceptibility.
Further research with larger cohorts, well-defined phenotypes, and control for confounding factors is necessary.
Investigating multiple genes within the same pathway is crucial for a comprehensive understanding of genetic contributions to CP.