Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tissue reaction to intraperitoneally implanted catheter materials.

E S Wilkins1

  • 1Department of Chemical and Nuclear Engineering, University of New Mexico, Albuquerque 87131.

Journal of Biomedical Engineering
|March 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Towards implantable glucose sensors: a review.

Journal of biomedical engineering·1989
Same author

The coated wire electrode glucose sensor.

Hormone and metabolic research. Supplement series·1988
Same author

Cellulase immobilized on modified nylon for saccharification of cellulose.

Biotechnology and bioengineering·1987
Same author

Optimization of an implantable coated wire glucose sensor.

Journal of biomedical engineering·1986
Same author

Effect of aspirin and vitamins C and E on synovial rheumatoid arthritic and other cells.

Experientia·1979
Same author

Studies of the mechanism of action of the carotenoid crocetin.

Experientia·1979
Same journal

Comparative study of the function of the Abiomed polyurethane heart valve for use in left ventricular assist devices.

Journal of biomedical engineering·1993
Same journal

AZTDIS--a two-phase real-time ECG data compressor.

Journal of biomedical engineering·1993
Same journal

Validation of an automated method of three-dimensional finite element modelling of bone.

Journal of biomedical engineering·1993
Same journal

Three dimensional shape reconstruction and finite element analysis of femur before and after the cementless type of total hip replacement.

Journal of biomedical engineering·1993
Same journal

The Rancho EMG analyzer: a computerized system for gait analysis.

Journal of biomedical engineering·1993
Same journal

Preparation and in vivo evaluation of a newly developed bioglass ceramic.

Journal of biomedical engineering·1993
See all related articles

This study investigated novel intraperitoneal catheter designs to prevent tissue encapsulation and ensure continuous insulin delivery for implantable systems. Results suggest porous end plugs may allow vascularization, potentially improving long-term device function.

Area of Science:

  • Biomaterials Science
  • Medical Device Engineering
  • Regenerative Medicine

Background:

  • Intraperitoneal (i.p.) catheter encapsulation by tissue hinders long-term function of implantable devices like the Programable Implantable Medication System (PIMS).
  • Tissue reaction at the catheter tip leads to complications, necessitating improved catheter designs for sustained insulin delivery.

Purpose of the Study:

  • To develop novel i.p. catheter end plugs that prevent tissue encapsulation while maintaining insulin flow.
  • To evaluate the biocompatibility and tissue response to various materials for i.p. catheter applications.

Main Methods:

  • Two hypotheses were tested: (1) porous end plugs (100-300 microns) promote vascularized tissue ingrowth for insulin circulation, and (2) narrow pore diameter plugs (≤25 microns) inhibit tissue ingrowth but permit insulin flow.

Related Experiment Videos

  • Biological responses to polyurethane, polyether-urethane, alumina-coated Teflon, pyrolytic carbon, polyethylenes, hydroxyapatite, bioglass, and expanded Teflon were assessed.
  • Materials were fabricated into end plugs and implanted intraperitoneally in 12 dogs for 12 weeks.

    • Main Results:

    • Varying degrees of tissue encapsulation and vascularization were observed around the catheter tips.
    • The study identified differences in tissue response based on material type and pore size.
    • Thin capsules with differing blood supply were noted surrounding the explanted catheter end plugs.

    Conclusions:

    • The study provides insights into material selection and design strategies for i.p. catheters to mitigate tissue encapsulation.
    • Further research is needed to optimize end plug porosity and material composition for successful long-term i.p. insulin delivery systems.
    • Successful development of these catheters could significantly improve management of conditions requiring chronic i.p. insulin therapy.