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Maternal and paternal age, birth order and interpregnancy interval evaluation for cleft lip-palate
Daniella Reis Barbosa Martelli1, Kaliany Wanessa da Cruz, Letízia Monteiro de Barros
1Universidade estadual de Montes Claros, Brazil.
Insights
Maternal age is linked to an increased risk of cleft lip and palate (CL/P), a common congenital condition. Other factors like paternal age and birth order were not significant in this study.
Area of Science:
- Craniofacial anomalies research
- Pediatric congenital conditions
- Environmental epidemiology
Background:
- Cleft lip and palate (CL/P) are the most frequent congenital craniofacial malformations.
- Understanding risk factors is crucial for prevention and early intervention strategies.
Purpose of the Study:
- To investigate potential environmental risk factors associated with non-syndromic cleft lip and palate (CL/P).
- To analyze demographic and parental factors in relation to CL/P occurrence.
Main Methods:
- A case-controlled study involving 100 children with CL/P and 100 controls.
- Data collected via questionnaire on maternal/paternal age, birth order, and interpregnancy interval.
- Statistical analysis included relative risk, odds ratio, and bivariate/multivariate analysis using SPSS 17.0.
Main Results:
- The study included 200 children, with a slight male predominance (54%).
- Cleft palate was the most prevalent type (54%), followed by cleft lip (30%) and cleft lip and palate (16%).
- Brown, white, and black were the predominant skin colors observed.
Conclusions:
- Maternal age demonstrated a statistically significant association with an increased risk of CL/P.
- Paternal age, birth order, and interpregnancy interval were not found to be significant risk factors in this cohort.
- Further research with larger sample sizes is warranted to confirm these findings.
Unlabelled:
Cleft lip and palate (CL/P) are the most common congenital craniofacial anomalies.
Aim:
To evaluate environmental risk factors for non-syndromic CL/P in a reference care center in Minas Gerais.
Materials And Methods:
we carried out a case-controlled study, assessing 100 children with clefts and 100 children without clinical alterations. The analysis dimensions (age, skin color, gender, fissure classification, maternal and paternal age, birth order and interpregnancy interval), obtained from a questionnaire; and later we build a data base and the analyses were carried out by the SPSS 17.0 software. The results were analyzed with the relative risk for each variable, in order to estimate the odds ratio with a 95% confidence interval, followed by a bivariate and multivariate analysis.
Results:
among 200 children, 54% were males and 46% were females. As far as skin color is concerned most were brown, white and black, respectively. Cleft palates were the most common fissures found (54%), followed by lip cleft (30%) and palate cleft (16%).
Conclusion:
although with a limited sample, we noticed an association between maternal age and an increased risk for cleft lip and palate; however, paternal age, pregnancy order and interpregnancy interval were not significant.
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