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Vitamin D metabolism.

H F Deluca

    Clinical Endocrinology
    |December 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Recent research highlights vitamin D

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    Same author

    Short-term regulation of the renal vitamin D receptor in rats by 1,25-dihydroxycholecalciferol is calcium insensitive.

    The Journal of nutrition·1992
    Same author

    Baculovirus-mediated expression of retinoic acid receptor type gamma in cultured insect cells reveals a difference in specific DNA-binding behavior with the 1,25-dihydroxyvitamin D3 receptor.

    Proceedings of the National Academy of Sciences of the United States of America·1992
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    Up-regulation of the vitamin D receptor in response to 1,25-dihydroxyvitamin D3 results from ligand-induced stabilization.

    The Journal of biological chemistry·1992
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    New concepts of vitamin D functions.

    Annals of the New York Academy of Sciences·1992
    Same author

    Sequences in the human parathyroid hormone gene that bind the 1,25-dihydroxyvitamin D3 receptor and mediate transcriptional repression in response to 1,25-dihydroxyvitamin D3.

    Proceedings of the National Academy of Sciences of the United States of America·1992
    Same author

    A new, highly sensitive assay for 1,25-dihydroxyvitamin D not requiring high-performance liquid chromatography: application of monoclonal antibody against vitamin D receptor to radioreceptor assay.

    Analytical biochemistry·1992

    Area of Science:

    • Biochemistry
    • Endocrinology
    • Metabolic Bone Disease

    Background:

    • Vitamin D's crucial role in calcium and phosphorus metabolism is increasingly understood.
    • Vitamin D is a precursor to a vital hormone regulating bone mineralization and preventing hypocalcemic tetany.
    • Potential role of vitamin D in preventing degenerative bone diseases like osteoporosis is under investigation.

    Purpose of the Study:

    • To summarize recent findings on vitamin D metabolism and function.
    • To discuss the implications of these findings for treating metabolic bone diseases.
    • To review the clinical use of vitamin D analogues like 1alpha-hydroxyvitamin D3.

    Main Methods:

    • Review of recent scientific literature on vitamin D.
    • Analysis of clinical data regarding vitamin D and bone health.

    Related Experiment Videos

  • Discussion of biochemical pathways involved in vitamin D metabolism.

    • Main Results:

    • Vitamin D is essential for bone mineralization and preventing hypocalcemic tetany.
    • Vitamin D may play a role in preventing osteoporosis.
    • 1alpha-hydroxyvitamin D3 is an effective treatment for various clinical conditions.

    Conclusions:

    • Vitamin D's hormonal functions are critical for bone health.
    • Further research into vitamin D's role in degenerative bone diseases is warranted.
    • Vitamin D analogues offer promising therapeutic options for metabolic bone disorders.