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Transmission of human poliomyelitis virus to mice

A MILZER, C L BYRD, S O LEVINSON

    Journal of Bacteriology
    |March 27, 2010
    PubMed
    Abstract

    No abstract available in PubMed .

    Keywords:
    POLIOMYELITIS/transmission

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    Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...