Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sedatives and Hypnotics Drugs: Miscellaneous Agents01:17

Sedatives and Hypnotics Drugs: Miscellaneous Agents

Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Management of Insomnia01:19

Management of Insomnia

The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
Sedatives and Hypnotics Drugs: Benzodiazepines01:19

Sedatives and Hypnotics Drugs: Benzodiazepines

Benzodiazepines have both sedative and hypnotic properties. They include compounds such as diazepam (Valium) and alprazolam (Xanax). Structurally, their cores are similar, consisting of the fusion of a benzene ring and a diazepine ring, but they share a common mechanism of action in the central nervous system (CNS).
Benzodiazepines work by enhancing the effects of the inhibitory neurotransmitter GABA. They bind to the GABAA receptor, increasing its affinity for GABA, which opens chloride...
Sedatives and Hypnotics: Overview01:23

Sedatives and Hypnotics: Overview

Sedatives are drugs that alleviate anxiety, while hypnotics induce sleep. Both classes of medication suppress neuronal activity, leading to a calming effect for sedatives and facilitating sleep for hypnotics.
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
CNS Depressants: Barbiturates and Benzodiazepines01:14

CNS Depressants: Barbiturates and Benzodiazepines

CNS depressants include drugs from the category of barbiturates and benzodiazepines. They are valuable medications for managing anxiety disorders and insomnia. Barbiturates, once used to induce and maintain sleep, have been replaced mainly by benzodiazepines due to barbiturate's toxicity, tolerance, and overdose risks. They interact with GABAA receptors, leading to sedation at low doses and potentially coma and death at higher doses. Phenobarbital, a long-acting barbiturate, possesses...
REM Sleep Behavior Disorder01:15

REM Sleep Behavior Disorder

REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transforming qualitative research: The AQUATIC approach to AI-driven data analysis.

Digital health·2026
Same author

A model of new-onset refractory status epilepticus (NORSE) using intrahippocampal kainic acid in adolescent mice.

Epilepsy research·2026
Same author

Dreams of the deceased: A scoping and mixed-methods systematic review.

Sleep medicine·2026
Same author

Father involvement in pregnancy and attachment to their baby: Depression and partner relationships in a sample of Black fathers.

Infant mental health journal·2025
Same author

Modeling the Tradeoff Between Water Loss, Chlorine Residuals, and Trihalomethanes in Rural Appalachia, USA.

Water·2025
Same author

A systematic review of latent class analyses of adult polysubstance use patterns.

Experimental and clinical psychopharmacology·2025
Same journal

Cancer Patients with Neuropathic Pain: Pharmacist-Led Recommendation and Management and Mirogabalin Outcomes in a Single-Center Retrospective Observational Cohort.

Journal of pain & palliative care pharmacotherapy·2026
Same journal

Cost-Effectiveness of Integrative Pain Management for Chronic Pain: A Systematic Review of Economic Evaluation.

Journal of pain & palliative care pharmacotherapy·2026
Same journal

High-Dose Monotherapy or Combination Therapy in Neuropathic Pain: A Necessary Reflection.

Journal of pain & palliative care pharmacotherapy·2026
Same journal

The Price of Goodbye.

Journal of pain & palliative care pharmacotherapy·2026
Same journal

In the End, What Shall We Say?

Journal of pain & palliative care pharmacotherapy·2026
Same journal

The Use of Ketamine for Depression in Cancer Patients: A Systematic Review of Efficacy, Safety, and Clinical Applications.

Journal of pain & palliative care pharmacotherapy·2026
See all related articles

Related Experiment Video

Updated: Jun 14, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

Quetiapine for sleep.

Scott Yost1, Jacob White

  • 1College of Pharmacy, University of Utah, Salt Lake City, Utah 84112-5820, USA. scott.yost@utah.edu

Journal of Pain & Palliative Care Pharmacotherapy
|March 30, 2010
PubMed
Summary
This summary is machine-generated.

Quetiapine, an atypical antipsychotic, is explored for its use in aiding sleep for chronic pain patients. This discussion covers the scientific reasoning behind this treatment approach.

More Related Videos

High-Throughput Small Molecule Drug Screening For Age-Related Sleep Disorders Using Drosophila melanogaster
05:59

High-Throughput Small Molecule Drug Screening For Age-Related Sleep Disorders Using Drosophila melanogaster

Published on: October 20, 2023

Related Experiment Videos

Last Updated: Jun 14, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

High-Throughput Small Molecule Drug Screening For Age-Related Sleep Disorders Using Drosophila melanogaster
05:59

High-Throughput Small Molecule Drug Screening For Age-Related Sleep Disorders Using Drosophila melanogaster

Published on: October 20, 2023

Area of Science:

  • Pharmacology
  • Pain Management
  • Sleep Medicine

Background:

  • Chronic pain frequently disrupts sleep patterns.
  • Sleep disturbances can exacerbate pain perception and reduce quality of life.
  • Atypical antipsychotics are being investigated for non-psychiatric applications.

Purpose of the Study:

  • To discuss the rationale for using quetiapine (Seroquel) in chronic pain patients.
  • To explore the potential benefits of quetiapine for sleep disturbances associated with chronic pain.

Main Methods:

  • Literature review of studies on quetiapine's effects on sleep.
  • Analysis of pharmacological mechanisms relevant to pain and sleep.
  • Discussion of clinical observations and theoretical frameworks.

Main Results:

  • Quetiapine exhibits sedative properties due to its antihistaminic and anti-serotonergic effects.
  • Its efficacy in improving sleep quality in non-psychotic populations requires further investigation.
  • Potential side effects and contraindications must be considered.

Conclusions:

  • Quetiapine may offer a therapeutic option for sleep difficulties in chronic pain management.
  • Further research is warranted to establish optimal dosing and long-term safety.
  • Individual patient factors should guide treatment decisions.