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Pandemic influenza A (2009 H1N1) in children with acute lymphoblastic leukaemia

Cristian Launes1, Susana Rives, Albert Català

  • 1Departments of Paediatric Haematology, Hospital Sant Joan de Déu de Barcelona, Esplugues de Llobregat, Barcelona, Spain.

British Journal of Haematology
|March 30, 2010
PubMed

Insights

Pandemic influenza A (H1N1) in children with acute lymphoblastic leukemia (ALL) is uncommon. Intensive chemotherapy patients experienced severe illness, while those on maintenance therapy had mild symptoms.

Area of Science:

  • Pediatric Oncology
  • Infectious Diseases

Background:

  • Influenza A (2009-H1N1) typically causes mild illness but can be severe.
  • No prior reports exist on H1N1 in pediatric acute lymphoblastic leukemia (ALL) patients.

Observation:

  • This study observed ten consecutive pediatric ALL patients diagnosed with pandemic influenza A (H1N1).
  • Patients ranged from 3 to 12 years old and were treated with oseltamivir.
  • Two patients undergoing intensive chemotherapy developed pneumonia, with one requiring ventilatory support.

Findings:

  • Pediatric ALL patients on intensive chemotherapy were more susceptible to severe H1N1 influenza complications.
  • ALL patients on maintenance treatment experienced only mild H1N1 influenza symptoms.
  • No deaths were reported among the observed cohort.

Implications:

  • The findings highlight the importance of monitoring H1N1 influenza in pediatric ALL patients, especially those on intensive chemotherapy.
  • This suggests that the intensity of chemotherapy may influence H1N1 disease severity in pediatric ALL.
  • Further research into prophylactic and therapeutic strategies for this vulnerable population is warranted.

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