Related Experiment Video
Updated: Jun 14, 2026
Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
Published on: May 17, 2024
Maspin expression in gastrointestinal stromal tumors
Saduman Balaban Adim1, Gulaydan Filiz, Ozkan Kanat
1Department of Surgical Pathology, Uludag University, Faculty of Medicine, Gorukle, Bursa, 16059, Turkey. sadumanbalaban@hotmail.com
Background:
To investigate the role of maspin expression in the progression of gastrointestinal stromal tumors, and its value as a prognostic indicator.
Methods:
In the study 54 patients with GIST diagnosis were included in Uludag University of Faculty of Medicine, Department of Pathology between 1997-2007. The expression of maspin in 54 cases of gastrointestinal stromal tumor was detected by immunohistochemistry and compared with the clinicopathologic tumor parameters.
Results:
The positive expression rates for maspin in the GISTs were 66.6% (36 of 54 cases). Maspin overexpression was detected in 9 of 29 high risk tumors (31%) and was significantly higher in very low/low (78.6%) and intermediate-risk tumors (63.6%) than high-risk tumors.
Conclusions:
Maspin expression might be an important factor in tumor progression and patient prognosis in GIST. In the future, larger series may be studied to examine the prognostic significance of maspin in GISTs and, of course, maspin expression may be studied in different mesenchymal tumors.
