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Related Concept Videos

M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...

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Related Experiment Video

Updated: Jun 14, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

CDK-Taverna: an open workflow environment for cheminformatics.

Thomas Kuhn1, Egon L Willighagen, Achim Zielesny

  • 1Chemoinformatics and Metabolism, European Bioinformatics Institute, Cambridge, UK.

BMC Bioinformatics
|March 30, 2010
PubMed
Summary
This summary is machine-generated.

This study introduces CDK-Taverna, an open-source cheminformatics workflow solution combining Taverna and the Chemistry Development Kit. It offers over 160 cheminformatics tasks, supporting open science and providing a free alternative to proprietary tools.

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Workflow and Tools for Crystallographic Fragment Screening at the Helmholtz-Zentrum Berlin
06:29

Workflow and Tools for Crystallographic Fragment Screening at the Helmholtz-Zentrum Berlin

Published on: March 3, 2021

Related Experiment Videos

Last Updated: Jun 14, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

Workflow and Tools for Crystallographic Fragment Screening at the Helmholtz-Zentrum Berlin
06:29

Workflow and Tools for Crystallographic Fragment Screening at the Helmholtz-Zentrum Berlin

Published on: March 3, 2021

Area of Science:

  • Bioinformatics
  • Cheminformatics
  • Computational Chemistry

Background:

  • Small molecules are crucial in bioinformatics for metabolomics and drug discovery.
  • Large open-access chemistry databases necessitate flexible data processing tools.
  • Open-source tools are essential for supporting open science initiatives.

Purpose of the Study:

  • To develop a novel, open-source workflow solution for cheminformatics tasks.
  • To integrate the Taverna workflow engine with the Chemistry Development Kit (CDK).
  • To facilitate knowledge discovery from large chemistry databases.

Main Methods:

  • Combined the Taverna workflow engine with the Chemistry Development Kit (CDK) library.
  • Developed over 160 specialized workers for diverse cheminformatics tasks.
  • Demonstrated applications through various usage scenarios.

Main Results:

  • Successfully created CDK-Taverna, an integrated open-source cheminformatics workflow solution.
  • Implemented a comprehensive suite of over 160 cheminformatics processing tools.
  • Showcased the utility and versatility of CDK-Taverna in practical applications.

Conclusions:

  • CDK-Taverna represents the first open-source cheminformatics workflow solution for the biosciences.
  • It offers a free, accessible alternative to proprietary cheminformatics software.
  • Future developments aim to enhance Taverna's user-friendliness and power, increasing CDK-Taverna's potential.