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Updated: Jun 14, 2026
09:23
Impedance-based Real-time Measurement of Cancer Cell Migration and Invasion
Published on: April 2, 2020
CXCR7 in tumorigenesis and progression
Kai-Lin Hou1, Ming-Gang Hao, Juan-Jie Bo
1Department of Urology, Renji Hospital, Shanghai 200001, P.R. China. bojuanjie@yahoo.com.cn.
Chinese Journal of Cancer
|March 30, 2010
Summary
Chemokines regulate cell movement and are crucial in cancer development. The CXCR7 receptor
Area of Science:
- Oncology and Immunology
- Molecular Biology
- Cellular Signaling
Background:
- Chemokines are small cytokines initially known for regulating immune cell trafficking.
- Emerging evidence highlights their critical roles in tumor initiation, promotion, and progression.
- CXCR7, a chemokine receptor, binds CXCL11 and CXCL12 with high affinity.
Purpose of the Study:
- To review the current understanding of CXCR7's role in cancer biology.
- To explore CXCR7's involvement in key cancer processes.
- To discuss potential therapeutic strategies targeting CXCR7.
Main Methods:
- Literature review of existing research on CXCR7 and cancer.
- Analysis of studies investigating CXCR7's function in tumor growth, survival, and metastasis.
- Examination of preclinical data on CXCR7-targeting agents.
Main Results:
- CXCR7 significantly influences cancer growth, survival, adhesion, invasion, and metastasis.
- CXCR7 plays a role in tumor angiogenesis and overall cancer progression.
- Targeting CXCR7 demonstrates potential in preclinical cancer models.
Conclusions:
- CXCR7 is a key mediator in multiple facets of cancer biology.
- Therapeutic strategies targeting CXCR7, including peptides, small molecules, and antibodies, show promise for cancer treatment.
- Further research into CXCR7 inhibition could lead to novel cancer therapies.
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