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Updated: Jun 14, 2026

High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing
Published on: January 22, 2019
[Molecular basis of HIV-1 latency - Part II: HIV-1 reactivation and therapeutic implications]
Thomas Cherrier1, Valentin Le Douce, Laetitia Redel
1Inserm Unité 575 Physiopathologie du système nerveux central, Institut de virologie, 3, rue Koeberlé, 67000 Strasbourg, France.
Abstract:
The latent HIV-1 reservoirs established early during infection present a major obstacle for virus eradication. Complete eradication of the virus from infected patients may require a purge of the reservoirs. Since the development of a HIV-1 vaccine is not achieved, and therefore remains a major challenge for the immunologists, future direction towards an effective curative therapy for HIV-1 infection will rely on the development of original therapeutic strategies which take into account latency, chronic replication and accessibility to tissue-sanctuary.
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