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Updated: Jun 14, 2026

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
08:54

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds

Published on: February 14, 2018

[Antifungal agents for onychomycoses]

Alfonso Javier Carrillo-Muñoz1, Cristina Tur-Tur, Juan Manuel Hernández-Molina

  • 1Departamento de Microbiología, Associació catalana d'Intel ligéncia Artificial (ACIA), Barcelona, España. acarrillo@aciam.es

Revista Iberoamericana De Micologia
|March 30, 2010
PubMed

Insights

Nail fungal infections present significant treatment challenges, often leading to therapeutic failure. Ongoing research is crucial for developing new antifungal agents and combination therapies to combat resistant microorganisms.

Area of Science:

  • Dermatology
  • Mycology
  • Infectious Diseases

Context:

  • Nail fungal infections (onychomycosis) are a prevalent and challenging dermatological issue.
  • High rates of therapeutic failure are associated with current treatment protocols.
  • Factors contributing to complications include long treatment durations, inadequate therapies, and misdiagnosis.

Purpose:

  • To highlight the difficulties in managing nail fungal infections.
  • To underscore the limitations of existing antifungal treatments.
  • To emphasize the need for novel therapeutic strategies and research.

Summary:

  • Nail fungal infections are a major dermatological problem characterized by high rates of treatment failure.
  • Complications arise from prolonged treatments, incorrect therapies, diagnostic errors, nail alterations, and resistant microbes.
  • While new antifungal agents exist, none are completely effective, necessitating continued research.

Impact:

  • Informs clinicians about the complexities of treating onychomycosis.
  • Guides researchers in developing more effective antifungal drugs and combination therapies.
  • Contributes to the understanding of factors leading to treatment resistance in nail fungi.

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