A female advantage in basic face recognition is absent in schizophrenia

Healthy females outperform males on face recognition tasks. Relative to healthy individuals, schizophrenia patients are impaired at face perception. Yet, it is unclear whether the female advantage found in healthy controls is preserved in females with schizophrenia. In the present study, we compared male and female patients and healthy controls on two basic face perception tasks - detection and identity discrimination. In the detection task, subjects located an upright or inverted line-drawn face (or tree) embedded within a larger line-drawing. In the identity discrimination task, subjects determined which of two side-by-side face images matched an earlier presented face image. Healthy females were significantly more accurate than healthy males on face detection, but not on identity discrimination. However, female patients were not more accurate than male patients on either task. On both upright face detection and face identity discrimination, healthy controls significantly outperformed patients. Patients' performance on face detection was closely associated with tree detection and IQ scores, as well as level of psychosis. This pattern of results suggests that a female advantage in basic face perception is no longer available in schizophrenia, and that this absence may be related to a generalized deficit factor which acts to level performance across sexes, and putative changes in sex-related neurobiological differences associated with schizophrenia.