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Prenatal diagnosis: what do we know of long-term outcomes?

D F M Thomas1

  • 1Department of Paediatric Urology, Clinical Sciences Building, St James's University Hospital, Leeds LS9 7TF, UK. d.f.m.thomas@leeds.ac.uk

Journal of Pediatric Urology
|March 30, 2010
PubMed

Insights

Long-term outcomes for prenatal diagnosis of uropathies are increasingly available. This review analyzes evidence beyond 5 years, focusing on surgical indications and impacts on families and services.

Area of Science:

  • Pediatric Urology
  • Prenatal Diagnosis
  • Uropathies

Background:

  • Prenatal diagnosis in pediatric urology has existed for over 20 years.
  • Published literature predominantly features short-to-medium-term follow-up data.
  • There is a growing availability of long-term outcome data for prenatally detected anomalies.

Purpose of the Study:

  • To analyze evidence on long-term outcomes (≥5 years, especially ≥10 years) for prenatally diagnosed uropathies.
  • To consider the natural history and outcomes of conservatively managed uropathies.
  • To evaluate evidence-based indications for surgical intervention.

Main Methods:

  • Review of published and unpublished studies with mean or median follow-up exceeding 5 years.
  • Emphasis on studies with follow-up at 10 years and beyond.
  • Appraisal of evidence for conservative management versus surgical intervention.

Main Results:

  • Analysis of long-term outcomes for various prenatally detected uropathies.
  • Evaluation of the natural history of conservatively managed conditions.
  • Assessment of evidence supporting surgical intervention.

Conclusions:

  • Prenatal diagnosis offers benefits and drawbacks for children and parents.
  • Long-term outcome data is crucial for informed management decisions.
  • Prenatal diagnosis impacts pediatric urology service delivery and specialist training.

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