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Stabilizing and remodeling the blocked DNA replication fork: anchoring FANCM and the Fanconi anemia damage response
Larry H Thompson1, Nigel J Jones
1Biology and Biotechnology Division, L452, Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, CA 94551-0808, USA. thompson14@llnl.gov
Abstract:
In this issue of Molecular Cell, Yan et al. (2010) and Singh et al. (2010) identify an evolutionarily conserved FANCM-associated histone-fold MHF heterodimer (MHF1-MHF2) that promotes the remodeling of artificial replication forks and confers cellular resistance to DNA crosslinks and camptothecin.
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