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Decrease in PTEN and increase in Akt expression and neuron size in aged rat spinal cord.

Miguel Augusto Rodrigues de Amorim¹, Luis Miguel Garcia-Segura, Rodolfo Gustavo Goya

¹Instituto Cajal, CSIC, Madrid, Spain.

Experimental Gerontology

|March 30, 2010

Summary

This summary is machine-generated.

Aging reduces PTEN tumor suppressor gene expression in rat spinal cords, leading to increased neuron size. This age-related PTEN decrease and elevated pAkt may drive neuronal enlargement.

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Area of Science:

Neuroscience
Cell Biology
Aging Research

Background:

PTEN (Phosphatase and tensin homolog) is a critical tumor suppressor gene regulating cell size.
Cellular aging is associated with various morphological and functional changes in the nervous system.

Purpose of the Study:

To investigate the relationship between aging, PTEN expression, and neuronal size in the rat spinal cord.
To determine if age-related changes in PTEN and its downstream signaling pathways correlate with alterations in neuronal morphology.

Main Methods:

Western blotting was used to quantify total and phosphorylated PTEN (pPTEN) and phosphorylated Akt (pAkt) in young and aged rat spinal cords.
Spinal cord neurons were morphometrically analyzed to assess size and morphology.

Main Results:

Total PTEN, pPTEN, and total Akt levels were significantly higher in young rats compared to aged rats.
Phosphorylated Akt (pAkt) expression was significantly increased in aged rats.
A significant increase in the size of large motoneurons was observed in aged rats relative to young rats.

Conclusions:

Neuronal PTEN expression diminishes with age in the rat spinal cord.
Increased pAkt signaling and reduced PTEN in aged rats correlate with enlarged neuronal size.
Age-related changes in PTEN/pAkt signaling may contribute to neuronal hypertrophy in the aging spinal cord.