Related Experiment Video
Updated: Jun 14, 2026

Procedures for In Vitro Cultivation of Treponema pallidum, the Syphilis Spirochete
Published on: January 24, 2025
Complete genome sequence and annotation of the Treponema pallidum subsp. pallidum Chicago strain
Lorenzo Giacani1, Brendan M Jeffrey, Barbara J Molini
1Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington 98195, USA. giacal@u.washington.edu
Abstract:
In syphilis research, the Nichols strain of Treponema pallidum, isolated in 1912, has been the most widely studied. Recently, important differences among T. pallidum strains emerged; therefore, we sequenced and annotated the Chicago strain genome to facilitate and encourage the use of this strain in studying the pathogenesis of syphilis.
Related Concept Videos
Bacterial Phylum Spirochaetes
Genome Annotation and Assembly
Bacterial Phylum Chlamydiae
Modern Molecular Taxonomy
