Related Experiment Video

Updated: Jun 14, 2026

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation
09:10

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation

Published on: July 27, 2022

Affects of ionizing radiation on T-cell population lymphocyte: a risk factor of irritable bowel syndrome

M R Sheikh Sajjadieh1, L V Kuznetsova, V B Bojenko

  • 1Department of Clinical Immunology & Allergology, National Medical Academy for Post Graduate Education, Kiev, Ukraine. mohammad_esfahan@yahoo.com

Toxicology and Industrial Health
|March 30, 2010
PubMed

Insights

Children in Chernobyl-affected areas with irritable bowel syndrome show altered T-cell populations. This immune system change in T-lymphocytes (CD3+, CD4+, CD8+) may link radiation exposure to IBS in pediatric populations.

Area of Science:

  • Environmental Medicine
  • Pediatric Immunology
  • Radiation Health

Background:

  • Irritable bowel syndrome (IBS) is prevalent in Ukrainian children, potentially linked to Chernobyl disaster health effects.
  • Investigating the immune status of children in radiation-contaminated areas is crucial for understanding IBS etiology.

Purpose of the Study:

  • To determine the T-cell population status in children diagnosed with irritable bowel syndrome.
  • To assess the correlation between living in a contaminated area and changes in T-lymphocyte subsets.

Main Methods:

  • Comparative analysis of T-lymphocyte subsets (CD3+, CD4+, CD8+) and CD4/CD8 ratio in 75 children with IBS from a contaminated zone and 20 healthy controls.
  • Internal radiation activity measured by gamma-ray spectrometry.
  • Peripheral blood leukocyte analysis.

Main Results:

  • Significant decrease in T-lymphocytes (CD3+) and T-helper cells (CD4+) in IBS patients compared to controls (p < 0.001).
  • Significant increase in T-cytotoxic cells (CD8+) in IBS patients compared to controls (p < 0.05).
  • Significantly reduced CD4/CD8 ratio observed in all study groups compared to the control group (p < 0.001).

Conclusions:

  • Cellular immune status is altered in children residing in Chernobyl-contaminated areas.
  • Observed changes in T-lymphocyte populations may be associated with a higher incidence of irritable bowel syndrome in these children.

More Related Videos

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice07:34

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

Published on: December 16, 2021

Chronic Salmonella Infection Induced Intestinal Fibrosis08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Related Concept Videos

Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
Irritable Bowel Syndrome01:23

Irritable Bowel Syndrome

DefinitionIrritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by recurrent combinations of abdominal pain, bloating, diarrhea, or constipation.Pathophysiology of irritable bowel syndromeIts pathophysiology is multifactorial, involving disturbances in motility, sensory processing, microbial balance, barrier integrity, and gut–brain communication. These mechanisms interact to produce symptoms that vary across IBS subtypes.Altered Motility PatternsDisordered...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...