Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for injury repair.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The prefrontal cortex outputs to the amygdala facilitate threat-discrimination learning.

bioRxiv : the preprint server for biology·2026
Same author

The Neuronal Hypofunction of Subdivisions of the Prefrontal Cortex Shows Differential Effects on Contingency Judgment Learning to Gauge Fear Responses.

Neuroscience insights·2024
Same author

Prefrontal multistimulus integration within a dedicated disambiguation circuit guides interleaving contingency judgment learning.

Cell reports·2024
Same author

Differential fear conditioning generates prefrontal neural ensembles of safety signals.

Behavioural brain research·2018
Same author

Long-Lasting Effects of Prenatal Ethanol Exposure on Fear Learning and Development of the Amygdala.

Frontiers in behavioral neuroscience·2018
Same author

Rubinstein-Taybi Syndrome and Epigenetic Alterations.

Advances in experimental medicine and biology·2017

Related Experiment Video

Updated: Jun 14, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

Manipulating the brain with epigenetics

Edward Korzus

    Nature Neuroscience
    |March 30, 2010
    PubMed
    Summary

    No abstract available in PubMed .

    More Related Videos

    Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain
    13:11

    Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

    Published on: July 12, 2012

    Genetic Manipulation of the Mouse Developing Hypothalamus through In utero Electroporation
    11:48

    Genetic Manipulation of the Mouse Developing Hypothalamus through In utero Electroporation

    Published on: July 24, 2013

    Related Experiment Videos

    Last Updated: Jun 14, 2026

    Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
    10:28

    Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

    Published on: September 20, 2018

    Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain
    13:11

    Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

    Published on: July 12, 2012

    Genetic Manipulation of the Mouse Developing Hypothalamus through In utero Electroporation
    11:48

    Genetic Manipulation of the Mouse Developing Hypothalamus through In utero Electroporation

    Published on: July 24, 2013