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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...

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Related Experiment Video

Updated: Jun 14, 2026

Pattern-based Search of Epigenomic Data Using GeNemo
06:38

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

Epigenetic marks identify functional elements.

Randall H Morse

    Nature Genetics
    |March 30, 2010
    PubMed
    Summary

    Identifying regulatory elements controlling gene expression is challenging due to their distance from target genes. A new model predicts functional elements in androgen receptor response using histone modifications and chromatin dynamics.

    Area of Science:

    • Genomics
    • Molecular Biology
    • Epigenetics

    Background:

    • Identifying distal regulatory elements like enhancers and transcription factor binding sites is crucial for understanding cell-specific gene regulation in eukaryotes.
    • These elements can be located hundreds of kilobases away from their target promoters, posing significant identification challenges.
    • Androgen receptor (AR) signaling plays a vital role in various physiological processes and diseases, making the study of its regulatory elements highly relevant.

    Discussion:

    • This study introduces a novel predictive model for identifying functional regulatory elements.
    • The model leverages histone modifications and chromatin dynamics as key indicators of regulatory element activity.
    • This approach addresses the challenge of identifying distal elements by focusing on their epigenetic signatures.

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    Last Updated: Jun 14, 2026

    Pattern-based Search of Epigenomic Data Using GeNemo
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    Pattern-based Search of Epigenomic Data Using GeNemo

    Published on: October 8, 2017

    Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay (EMSA) and DNA-affinity Precipitation Assay (DAPA)
    11:35

    Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay (EMSA) and DNA-affinity Precipitation Assay (DAPA)

    Published on: August 21, 2016

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    HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries

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    Key Insights:

    • A predictive model integrating histone modifications and chromatin dynamics can accurately identify functional elements involved in androgen receptor response.
    • The findings highlight the importance of epigenetic marks in deciphering complex gene regulatory networks.
    • This method offers a powerful tool for dissecting the regulatory landscape of hormone-driven gene expression.

    Outlook:

    • Further refinement of the model could enable genome-wide prediction of enhancer function.
    • Application of this model to other transcription factor response pathways could yield significant insights.
    • This approach may accelerate the discovery of novel therapeutic targets in diseases associated with aberrant gene regulation.