Clinico-pathologic patterns of extremity liposarcoma.

Area of Science:

• Oncology
• Pathology
• Surgical Oncology

Background:

• Liposarcoma originates from primitive cells differentiating into adipose tissue.
• Extremity liposarcoma represents a significant subset of soft tissue sarcomas.
• Understanding its clinico-pathological pattern is crucial for effective management.

Purpose of the Study:

• To delineate the clinico-pathological characteristics of liposarcoma affecting the extremities.
• To analyze demographic, clinical, and histological features of extremity liposarcoma in Lagos, Nigeria.
• To provide insights into the presentation and initial management of these tumors.

Main Methods:

• A descriptive study was conducted on patients with histologically confirmed extremity liposarcoma.
• Data collected included patient demographics, lesion location, histological type, and clinical stage.
• Analysis focused on clinico-pathological patterns and initial treatment approaches.

Main Results:

• Liposarcoma constituted 27.3% of soft tissue sarcomas, exclusively in males (6/6).
• The myxoid subtype was most prevalent (50%), predominantly affecting the thigh (83.3%).
• All patients presented at stage T2bNoMo, with most undergoing limb salvage surgery and radiotherapy.

Conclusions:

• Liposarcoma is the leading extremity soft tissue sarcoma in the studied population.
• Myxoid liposarcoma is the most common histological subtype encountered.
• Challenges in follow-up limited the assessment of survival and recurrence rates.