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Published on: January 22, 2018
[Gastric MALT-type lymphoma. Pathology, pathogenesis, diagnostics and therapy]
1Institut für Pathologie, Klinikum Aschaffenburg, Am Hasenkopf 63704, Aschaffenburg. Matthias.Eck@klinikum-aschaffenburg.de
Der Pathologe
|March 30, 2010
Summary
Helicobacter pylori infection is a key factor in developing gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Treatment involves H. pylori eradication, potentially combined with other therapies, aiming for complete lymphoma regression.
Area of Science:
- Gastroenterology
- Oncology
- Pathology
Background:
- Helicobacter pylori infection is a primary driver of gastric mucosa-associated lymphoid tissue (MALT) lymphoma.
- Chronic H. pylori gastritis stimulates B-lymphocyte proliferation, leading to neoplastic transformation.
- MALT lymphoma shares histological similarities with physiological MALT, characterized by lymphoepithelial lesions.
Purpose of the Study:
- To elucidate the role of H. pylori in gastric MALT lymphoma development.
- To describe the diagnostic criteria and histological features of MALT lymphoma.
- To outline therapeutic strategies for gastric MALT lymphoma.
Main Methods:
- Histopathological examination of gastric biopsies.
- Immunohistochemistry for lymphoma phenotyping (CD20+, CD5-, CD10-, CD23-).
- Review of therapeutic modalities based on lymphoma type and stage.
Main Results:
- Gastric MALT lymphoma arises from H. pylori-induced chronic gastritis and B-lymphocyte proliferation.
- Key diagnostic feature is invasion and destruction of gastric epithelium, forming lymphoepithelial lesions.
- MALT lymphoma phenotype matches non-neoplastic marginal zone B-lymphocytes.
Conclusions:
- H. pylori eradication is crucial for treating gastric MALT lymphoma.
- Therapy is individualized, involving H. pylori eradication, radiochemotherapy, surgery, or combinations.
- The goal of treatment is complete lymphoma regression and cure.
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