Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Animal acoustic communication has a conserved optimal rhythm within the neural delta range.

PLoS biology·2026
Same author

Acceptability of DBS for psychiatric disorders by French psychiatrists: a network clustering analysis based on a mixed method study.

Comprehensive psychiatry·2026
Same author

Post-hoc analysis of adverse events during the EPOCH trial: reconsidering dosimetry.

European journal of nuclear medicine and molecular imaging·2026
Same author

Baseline PSMA-ligand PET/CT as a predictive biomarker for early progression in metastatic castration-resistant prostate cancer patients undergoing [177Lu]Lu-PSMA-617 radioligand therapy.

Annals of nuclear medicine·2026
Same author

Unravelling the structure of broadband white-emitting silver nanoclusters stabilized in sulfur-doped zeolites.

Nanoscale·2026
Same author

Influence of attention mechanisms on cerebellar and basal ganglia activity during vocal emotion decoding.

NeuroImage·2026

Related Experiment Video

Updated: Jun 14, 2026

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
09:46

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Published on: March 8, 2015

Subthalamic nucleus stimulation affects limbic and associative circuits: a PET study.

Florence Le Jeune1, Julie Péron, Didier Grandjean

  • 1Service de Médecine Nucléaire, Centre Eugène Marquis, rue de la Bataille Flandres Dunkerque, 35042 Rennes, France. f.lejeune@rennes.fnclcc.fr

European Journal of Nuclear Medicine and Molecular Imaging
|March 30, 2010
PubMed
Summary

High-frequency deep brain stimulation (STN DBS) for Parkinson's disease (PD) impacts associative and limbic circuits. These brain changes after STN DBS may explain cognitive and emotional modifications in PD patients.

More Related Videos

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test
07:14

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

Published on: May 31, 2016

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery
12:04

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Published on: January 6, 2011

Related Experiment Videos

Last Updated: Jun 14, 2026

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
09:46

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Published on: March 8, 2015

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test
07:14

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

Published on: May 31, 2016

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery
12:04

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Published on: January 6, 2011

Area of Science:

  • Neuroscience
  • Neurology
  • Functional Neuroimaging

Background:

  • High-frequency deep brain stimulation of the subthalamic nucleus (STN DBS) is effective for advanced Parkinson's disease (PD) motor symptoms.
  • However, STN DBS can lead to cognitive, motivational, and emotional changes, suggesting STN involvement in broader neural networks.

Purpose of the Study:

  • To identify cortical and subcortical brain regions affected by STN DBS.
  • To assess the STN's functional role and explain neuropsychological changes post-STN DBS in PD.

Main Methods:

  • Utilized (18)F-FDG PET to measure resting-state glucose metabolism in 20 PD patients before and after STN DBS.
  • Compared metabolic data with 13 age-matched healthy controls using SPM2 statistical analysis.

Main Results:

  • No pre-stimulation metabolic abnormalities were observed in associative or limbic circuitry in PD patients compared to controls.
  • Following STN DBS, significant metabolic modifications were detected in brain regions associated with limbic and associative circuits.

Conclusions:

  • Metabolic findings confirm the STN's crucial role in associative and limbic basal ganglia circuits.
  • Results provide a basis for future research into neuropsychological changes and metabolic alterations related to STN DBS, enhancing understanding of the STN's function.