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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

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Updated: Jun 14, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Transplant tolerance: progress and challenges.

Federica Casiraghi1, Sistiana Aiello, Giuseppe Remuzzi

  • 1Mario Negri Institute for Pharmacological Research, Transplant Research Center Chiara Cucchi de Alessandri e Gilberto Crespi, Ranica, Bergamo - Italy.

Journal of Nephrology
|March 30, 2010
PubMed
Summary
This summary is machine-generated.

Organ transplantation requires lifelong immunosuppression, increasing risks. New tolerance induction strategies show promise but face challenges from human immune responses, necessitating further research for improved transplant outcomes.

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Last Updated: Jun 14, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Orthotopic Hind Limb Transplantation in the Mouse
07:15

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Published on: February 12, 2016

Murine Full-thickness Skin Transplantation
07:59

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Published on: January 2, 2017

Area of Science:

  • Immunology
  • Transplantation Biology
  • Clinical Medicine

Background:

  • Organ transplantation is a vital therapy for organ failure.
  • Chronic immunosuppression post-transplant elevates risks of infection and cancer.
  • Current tolerance induction strategies aim to prevent immune rejection of the transplanted organ.

Purpose of the Study:

  • To evaluate the efficacy of regulatory T cell (Treg) induction protocols in clinical settings.
  • To identify barriers to tolerance induction in human transplant recipients.
  • To explore mechanisms of immune modulation for enhanced allograft survival.

Main Methods:

  • Review of experimental data on graft survival and tolerance induction strategies.
  • Analysis of challenges posed by human immune system components like memory T cells and innate immunity.
  • Consideration of studies on spontaneously tolerant patients.

Main Results:

  • Existing tolerance protocols face significant hurdles in humans due to memory T cells and innate immune responses.
  • Inflammation-induced cytokines can inhibit regulatory T cell function and promote T effector responses.
  • Rodent models may not fully recapitulate human immune responses to transplantation.

Conclusions:

  • Further understanding of cellular and molecular mechanisms is crucial for overcoming tolerance induction barriers.
  • Targeting multiple immune system levels through combined strategies is a promising therapeutic direction.
  • Investigating naturally tolerant patients may offer insights into successful transplant acceptance.