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Related Concept Videos

Combinatorial Gene Control02:33

Combinatorial Gene Control

Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the addition of a...
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Structure of a Gene01:30

Structure of a Gene

A gene is the fundamental unit of heredity. Every individual has two copies of each gene, one inherited from each parent. Although most people contain the same genes, there is a small fraction that is slightly different amongst people. A gene with a small difference in its sequence of DNA bases forms different alleles, contributing to different phenotypes.
However, only 1% of the DNA is composed of genes that encode proteins; the rest, 99% is non-coding DNA. This non-coding DNA performs...
Cis-regulatory Sequences02:02

Cis-regulatory Sequences

Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...

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Quantification of Information Encoded by Gene Expression Levels During Lifespan Modulation Under Broad-range Dietary Restriction in C. elegans
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Numbers on the edges: a simplified and scalable method for quantifying the gene regulation function.

Raul Fernandez-Lopez1, Irene Del Campo, Raúl Ruiz

  • 1Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Universidad de Cantabria-CSIC-IDICAN, Cardenal Herrera Oria s/n, 39011 Santander, Spain.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|March 30, 2010
PubMed
Summary

Gene regulation function (GRF) describes promoter behavior. A new, scalable method accurately measures GRF, improving understanding of gene control networks and predicting circuit behavior.

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Quantification of Information Encoded by Gene Expression Levels During Lifespan Modulation Under Broad-range Dietary Restriction in C. elegans
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Published on: December 7, 2021

Area of Science:

  • Systems Biology
  • Molecular Biology
  • Bioinformatics

Background:

  • Gene regulation is fundamental to biological control.
  • Transcriptional networks govern gene expression.
  • Quantifying promoter behavior is crucial for understanding gene regulation.

Purpose of the Study:

  • To describe the gene regulation function (GRF) as a key concept in biological control.
  • To review existing methods for GRF measurement and their limitations.
  • To introduce a novel, scalable method for GRF determination.

Main Methods:

  • Discussing theoretical and technical requirements for GRF measurement.
  • Developing a simplified and scalable method for capturing significant GRF parameters.
  • Validating the method through prediction of a simple genetic circuit's behavior.

Main Results:

  • Existing GRF measurement methods face scalability and accuracy trade-offs.
  • The proposed method is simplified, scalable, and captures essential GRF parameters.
  • The GRF successfully predicts the behavior of a simple genetic circuit.

Conclusions:

  • Accurate GRF measurement is essential for understanding gene regulatory mechanisms.
  • The new method enhances the scalability and applicability of GRF analysis.
  • Quantitative gene regulation analysis significantly advances comprehension of biological control systems.