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Disulfide bond cleavage: a redox reaction without electron transfer

Florian Hofbauer1, Irmgard Frank

  • 1Institut für Physikalische Chemie und Elektrochemie, Leibniz Universität Hannover, Callinstr. 3A, 30167 Hannover, Germany.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|March 30, 2010
PubMed
Summary

Mechanical force can trigger protein reduction. Car-Parrinello molecular dynamics simulations reveal that breaking disulfide bonds involves electron and proton transfer, elucidating the reaction mechanism.

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