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In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
Published on: August 12, 2017
CD52 gene polymorphism and its potential effect on the response to alemtuzumab in renal transplant recipients
Andrzej Oko1, Lucjan S Wyrwicz, Maciej Glyda
1Katedra i Klinika Nefrologii, Transplantologii i Chorób Wewnetrznych, Uniwersytetu Medycznego im. Karola Marcinkowskiego ul. Przybyszewskiego 49, 60-355 Poznań.
Abstract:
CD52 is a small glycopeptide leukocyte antigen present on selected subpopulations of human cells. From the clinical point of view this protein is an important target for therapeutic interventions aimed at leukocyte depletion in hematological malignancies and post-transplant immunosuppression. Recently, two variants of CD52--rs1071849 (A119G; Asn40Ser) and rs17645 (A123G; I1e41Met)--were discovered. We now report on the distribution of these variants in kidney graft recipients and controls. Our bioinformatics findings suggest that CD52 polymorphism may affect the efficiency of GPI anchor formation and thus may indirectly alter the response to anti-CD52 agents.
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