Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Vaccinations

Vaccinations

Drug Dosing: Geriatric Patients

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Improving Blood Pressure and Weight in Patients with Diabetes.

Journal of National Black Nurses' Association : JNBNA·2018

Same author

Implementing a Pediatric Fall Prevention Policy and Program.

Pediatric nursing·2018

Same author

Appointment Reminders to Decrease 30-Day Readmission Rates to Inpatient Psychiatric Hospitals.

Professional case management·2018

Same author

Increasing physical activity for veterans in the Mental Health Intensive Case Management Program: A community-based intervention.

Perspectives in psychiatric care·2017

Same author

Reflections on Mentoring.

Journal of gerontological nursing·2017

Same author

Diagnosis and management of pityriasis rosea.

The Nurse practitioner·2016

Search research articles

Related Experiment Video

Updated: Jun 14, 2026

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty

Published on: October 6, 2016

Travel immunization update for older adults.

Margaret P Spain¹, Barbara J Edlund

¹Medical University of South Carolina, College of Nursing, Charleston, South Carolina 29425, USA.

Journal of Gerontological Nursing

|March 31, 2010

Summary

Older adults traveling internationally need to prepare for healthy travel by staying updated on routine immunizations and seeking additional vaccines based on destination and health status.

Area of Science:

Geriatrics
Travel Medicine
Public Health

Background:

Older Americans are a significant demographic for travel, with increasing trends in international and Third World country travel.
This demographic increasingly travels with pre-existing health conditions, necessitating proactive health planning.
Current healthcare practices may not adequately address the unique travel health needs of older adults.

Purpose of the Study:

To emphasize the importance of healthy travel preparation for older adults.
To guide primary care providers in discussing international travel plans with older patients.
To highlight the necessity of timely immunization and health advice for international travel.

Main Methods:

Review of current travel trends among older adults.

More Related Videos

An Optimized Hemagglutination Inhibition (HI) Assay to Quantify Influenza-specific Antibody Titers

An Optimized Hemagglutination Inhibition (HI) Assay to Quantify Influenza-specific Antibody Titers

Published on: December 1, 2017

Immunization of Adult Zebrafish for the Preclinical Screening of DNA-based Vaccines

Immunization of Adult Zebrafish for the Preclinical Screening of DNA-based Vaccines

Published on: October 30, 2018

Related Experiment Videos

Last Updated: Jun 14, 2026

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty

Published on: October 6, 2016

An Optimized Hemagglutination Inhibition (HI) Assay to Quantify Influenza-specific Antibody Titers

An Optimized Hemagglutination Inhibition (HI) Assay to Quantify Influenza-specific Antibody Titers

Published on: December 1, 2017

Immunization of Adult Zebrafish for the Preclinical Screening of DNA-based Vaccines

Immunization of Adult Zebrafish for the Preclinical Screening of DNA-based Vaccines

Published on: October 30, 2018

Emphasis on proactive health screening during routine primary care visits.

Guidance on assessing immunization needs based on health status, itinerary, and destination risks.

Main Results:

Older adults require up-to-date routine immunizations before international travel.
Additional immunizations may be necessary, contingent on individual health, travel specifics, and destination risks.
Primary care providers play a crucial role in identifying travel plans and facilitating access to travel medicine resources.

Conclusions:

Proactive health planning and early preparation are essential for healthy international travel in older adults.
Primary care providers should routinely inquire about travel plans and provide tailored advice.
Knowledge of travel medicine resources is vital for healthcare providers to ensure appropriate referrals and care.