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Approaches to the discovery of pharmacogenomic markers in oncology: 2000-2010-2020

R Stephanie Huang1, M Eileen Dolan

  • 1Department of Medicine, University of Chicago, IL 60637, USA.

Pharmacogenomics
|March 31, 2010
PubMed

Insights

Pharmacogenomics is revolutionizing drug development and cancer treatment by identifying genetic markers for drug response and toxicity. Future research will integrate comprehensive genomic analysis for personalized medicine.

Area of Science:

  • Pharmacogenomics
  • Cancer Therapeutics
  • Molecular Biology

Background:

  • Pharmacogenomics plays a crucial role in advancing drug development and optimizing chemotherapy.
  • Identifying genetic markers is key to predicting patient response and toxicity to chemotherapeutic agents.

Purpose of the Study:

  • To highlight the growing importance of pharmacogenomics in drug development and clinical practice.
  • To emphasize the need for comprehensive genomic evaluation for personalized medicine.

Main Methods:

  • Utilizing candidate gene and genome-wide association studies to identify genetic markers.
  • Designing molecular targeted agents based on cancer-specific molecular alterations.

Main Results:

  • Pharmacogenomic approaches have identified genetic markers linked to chemotherapeutic outcomes.
  • Molecularly targeted therapies are being developed using advanced understanding of cancer genetics.

Conclusions:

  • Translating pharmacogenomic findings into clinical practice is a priority for the next decade.
  • Further research into rare SNPs, copy number variations, tandem repeats, and epigenetics will deepen the understanding of pharmacogenomics.

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