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Updated: Jun 14, 2026

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
Published on: October 31, 2025
[Application of endotracheal lavage in neonatal ventilator-associated pneumonia]
Xin-Zhu Lin1, Chang-An Ou-Yang, Ji-Dong Lai
1NICU of Maternal and Child Health Hospital of Xiamen, Xiamen, Fujian 361000, China. xinzhufj@yahoo.com.cn
Objective:
To study the efficacy of endotracheal lavage in neonatal ventilator-associated pneumonia (VAP).
Methods:
Fifty-eight neonates with VAP between January 2002 and December 2008 were randomly assigned to two groups: lavage and control (n=29 each). After withdrawal from ventilator, both groups received sensitive antibiotics therapy according to sputum culture results as well as supportive treatment. The lavage group was additionally treated with endotracheal lavage (2-3 times daily). The therapeutic effects were compared between the two groups.
Results:
There were no significant differences in the average time of mechanical ventilation between the lavage and the control groups. The effective rate in the lavage group (93%) was significantly higher than that in the control group (69%; p<0.05). Three percent of patients in the lavage group required twice or more mechanical ventilation compared with 24% in the control group (p<0.05). Blood gas analysis results were obviously improved in the lavage group 2 hrs after treatment (p<0.01).
Conclusions:
Endotracheal lavage can decrease the number in mechanical ventilation and improve therapeutic effects in neonates with VAP.
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