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[Comparison of therapeutic effects in severe nocturia: gradual versus immediate drug withdrawal]

Fang-Zheng Tang1, Ya-Lan Liu, Fei-Qiu Wen

  • 1Department of Pediatrics, Second Affiliated Hospital of Jinan University Medical College, Shenzhen, Guangdong 518020, China. annalyc@126.com

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|March 31, 2010
PubMed

Insights

Gradual drug withdrawal after treatment for severe nocturia (bedwetting) in children leads to better long-term outcomes than immediate cessation. This approach improves prognosis for nocturnal enuresis management.

Area of Science:

  • Pediatric Urology
  • Pharmacology
  • Clinical Medicine

Background:

  • Nocturnal enuresis (bedwetting) is a common condition in children.
  • Severe nocturia requires effective management strategies.
  • Understanding optimal drug withdrawal protocols is crucial for sustained treatment success.

Purpose of the Study:

  • To compare the long-term effectiveness of immediate versus gradual drug withdrawal in children with severe nocturia.
  • To evaluate the impact of different drug tapering schedules on enuresis recurrence.

Main Methods:

  • A randomized controlled trial involving 97 children with severe nocturia.
  • Two groups: immediate drug withdrawal (control) and gradual dose tapering (observed) after 12 weeks of treatment.
  • Enuresis frequency was assessed three months post-withdrawal.

Main Results:

  • Both groups achieved over 90% reduction in enuresis during treatment.
  • Significantly higher sustained enuresis reduction (92%) in the gradual withdrawal group compared to the immediate withdrawal group (60%) at three months (p<0.01).
  • No significant differences in adverse effects or medication compliance were observed.

Conclusions:

  • Gradual drug withdrawal schedules appear superior to immediate cessation for managing severe nocturia in children.
  • A phased approach to medication cessation may improve long-term prognosis and reduce relapse rates for nocturnal enuresis.
Abstract

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