Related Experiment Video
Updated: Jun 14, 2026

Multimodality Diagnosis of Mesenteric Ischemia
Published on: July 21, 2023
[Sclerosing mesenteritis]
Margarida Ferreira1, Amílcar F Silva, Manuela Meruje
1Serviços de Gastrenterologia, Medicina Interna, Anatomia Patológica e Cirurgia, Centro Hospitalar de Coimbra, Coimbra.
Abstract:
The Sclerosing Mesenteritis is a rare idiopathic disease. It represents the final stadium of progression of the chronic inflammatory illnesses of the intestinal mesentery, with predominance of fibrosis. The clinical manifestations are varied and unspecific. Diagnosis, that demands high degree of suspicion, can be presumed for imaging study, that discloses heterogeneous mass with tumor-like appearance, and confirmed on the basis of anatomo-pathological examination. The treatment is empirical and the prognostic is habitually favourable, over all in initial stadiums of the illness, being in a minority fatal. The authors describe the clinical case of a 50 years-old woman, admitted in the hospital for abdominal pain, ascitis and fever and that by radiological suspicion of peritoneal carcinomatosis and negative complementary study for primitive neoplasm, was submitted to an exploring laparotomy. Observed accented thickening of the mesentery that formed an extensive adherent conglomerate of bowel loops, whose biopsy had disclosed to be a sclerosing mesenteritis. Was verified an irrelevant answer to the treatment and an unfavourable, lethal, clinical course. The authors provide a literature review concerning the most relevant aspects of this disease.
Insights
Sclerosing mesenteritis is a rare idiopathic disease characterized by mesenteric fibrosis. This case highlights a fatal outcome despite diagnosis, emphasizing the need for further research into effective treatments for this rare condition.
Area of Science:
- Gastroenterology
- Pathology
Background:
- Sclerosing mesenteritis is a rare, idiopathic condition involving chronic inflammation and fibrosis of the intestinal mesentery.
- It often presents with non-specific symptoms, making early diagnosis challenging.
Observation:
- A 50-year-old woman presented with abdominal pain, ascites, and fever.
- Radiological imaging suggested peritoneal carcinomatosis, but further studies ruled out primary neoplasms.
- Exploratory laparotomy revealed significant mesenteric thickening and adherence of bowel loops.
Findings:
- Histopathological examination confirmed the diagnosis of sclerosing mesenteritis.
- The patient showed a poor response to empirical treatment, leading to a lethal clinical course.
Implications:
- This case underscores the diagnostic challenges and variable prognosis of sclerosing mesenteritis.
- It highlights the importance of high clinical suspicion for accurate diagnosis and timely management.
- Further research is needed to establish optimal treatment strategies and improve outcomes for patients with sclerosing mesenteritis.
Related Concept Videos
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Esophageal Achalasia
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Appendicitis
Renewal of Intestinal Stem Cells
Ascites
