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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Esophageal Achalasia01:27

Esophageal Achalasia

Esophageal achalasia is a chronic neurogenic disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent or ineffective peristalsis in the distal esophagus. This leads to a functional obstruction without a physical blockage, despite significant disruption of esophageal motility.EtiologyAchalasia is caused by degeneration of the myenteric (Auerbach's) plexus, specifically the loss of inhibitory ganglion cells that produce vasoactive intestinal peptide (VIP)...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Appendicitis01:19

Appendicitis

Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...
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Ascites

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Updated: Jun 14, 2026

Multimodality Diagnosis of Mesenteric Ischemia
05:07

Multimodality Diagnosis of Mesenteric Ischemia

Published on: July 21, 2023

[Sclerosing mesenteritis].

Margarida Ferreira1, Amílcar F Silva, Manuela Meruje

  • 1Serviços de Gastrenterologia, Medicina Interna, Anatomia Patológica e Cirurgia, Centro Hospitalar de Coimbra, Coimbra.

Acta Medica Portuguesa
|March 31, 2010
PubMed
Summary
This summary is machine-generated.

Sclerosing mesenteritis is a rare idiopathic disease characterized by mesenteric fibrosis. This case highlights a fatal outcome despite diagnosis, emphasizing the need for further research into effective treatments for this rare condition.

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Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Area of Science:

  • Gastroenterology
  • Pathology

Background:

  • Sclerosing mesenteritis is a rare, idiopathic condition involving chronic inflammation and fibrosis of the intestinal mesentery.
  • It often presents with non-specific symptoms, making early diagnosis challenging.

Observation:

  • A 50-year-old woman presented with abdominal pain, ascites, and fever.
  • Radiological imaging suggested peritoneal carcinomatosis, but further studies ruled out primary neoplasms.
  • Exploratory laparotomy revealed significant mesenteric thickening and adherence of bowel loops.

Findings:

  • Histopathological examination confirmed the diagnosis of sclerosing mesenteritis.
  • The patient showed a poor response to empirical treatment, leading to a lethal clinical course.

Implications:

  • This case underscores the diagnostic challenges and variable prognosis of sclerosing mesenteritis.
  • It highlights the importance of high clinical suspicion for accurate diagnosis and timely management.
  • Further research is needed to establish optimal treatment strategies and improve outcomes for patients with sclerosing mesenteritis.