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Updated: Jun 14, 2026

05:31
Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model
Published on: June 8, 2022
[Percutaneous stented pulmonary valve implantation]
Mads Ersbøll1, Lars Søndergaard
1Kardiologisk Klinik B 2014, Rigshospitalet, DK-2100 København Ø, Denmark. mads.ersboell@gmail.com
Ugeskrift for Laeger
|March 31, 2010
Summary
Percutaneous stented valve implantation (PPVR) offers a safe, minimally invasive treatment for right ventricular outflow tract issues. This procedure significantly improves hemodynamics and clinical status in patients with congenital cardiac malformations, avoiding reintervention in the short term.
Area of Science:
- Cardiovascular Surgery
- Interventional Cardiology
- Biomedical Engineering
Context:
- Congenital cardiac malformations frequently affect the right ventricular outflow tract.
- Biological valved conduits have limited longevity, leading to graft degeneration and right ventricular failure.
- Young patient age necessitates repeat surgeries, driving innovation in less invasive treatments.
Purpose:
- To evaluate the safety and efficacy of percutaneous stented valve implantation (PPVR) for right ventricular outflow tract reconstruction.
- To assess hemodynamic and clinical outcomes in patients treated with PPVR.
- To determine the need for reintervention following PPVR.
Summary:
- A retrospective study examined 13 patients (mean age 26 years) who underwent PPVR for conduit dysfunction (stenosis/regurgitation).
- Immediate hemodynamic improvement was observed, with significant reduction in pressure gradients and full valvular competence.
- No reinterventions were required at a mean follow-up of 141 days, indicating a safe and effective procedure.
Impact:
- PPVR provides significant hemodynamic and clinical improvement in patients with right ventricular outflow tract malformations.
- This minimally invasive approach is safe and effective, even in a low-volume setting.
- PPVR represents a promising alternative to repeat open-heart surgery for this patient population.

