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Published on: December 6, 2016
Nocturnal rostral fluid shift: a unifying concept for the pathogenesis of obstructive and central sleep apnea in men
Dai Yumino1, Stefania Redolfi, Pimon Ruttanaumpawan
1Toronto General Hospital/University Health Network, 9N-943, 200 Elizabeth St, Toronto, Ontario M5G 2C4, Canada.
Background:
Obstructive sleep apnea (OSA) and central sleep apnea are common in patients with heart failure. We hypothesized that in such patients, severity of OSA is related to overnight rostral leg fluid displacement and increase in neck circumference, severity of central sleep apnea is related to overnight rostral fluid displacement and to sleep Pco(2), and continuous positive airway pressure alleviates OSA in association with prevention of fluid accumulation in the neck.
Methods And Results:
In 57 patients with heart failure (ejection fraction
Conclusions:
Our findings suggest that nocturnal rostral fluid shift is a unifying concept contributing to the pathogenesis of both OSA and central sleep apnea in patients with heart failure.
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