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Related Experiment Video

Updated: Jun 14, 2026

Use of a Piglet Model for the Study of Anesthetic-induced Developmental Neurotoxicity (AIDN): A Translational Neuroscience Approach
06:38

Use of a Piglet Model for the Study of Anesthetic-induced Developmental Neurotoxicity (AIDN): A Translational Neuroscience Approach

Published on: June 11, 2017

Neurologic disease in a pig.

H B Gelberg1

  • 1Department of Biomedical Sciences, Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA. howard.gelberg@oregonstate.edu

Veterinary Pathology
|March 31, 2010
PubMed
Summary
This summary is machine-generated.

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Weaning piglets developed neurological signs like seizures and tremors. Histopathology revealed brain lesions consistent with sodium ion intoxication.

Area of Science:

  • Veterinary Neurology
  • Toxicology

Background:

  • Piglet neurological diseases can manifest with severe clinical signs.
  • Weaning is a critical period for young pigs, often associated with stress and potential health issues.

Observation:

  • Three 4-week-old piglets exhibited convulsions, obtundation, ataxia, hypermetria, and intention tremors post-weaning.
  • Gross necropsy revealed no significant lesions, but histologic examination showed significant brain abnormalities.

Findings:

  • Histopathology disclosed severe multifocal subcortical cerebral and cerebellar laminar necrosis.
  • Brain lesions included gitter cell proliferation and perivasculitis with lymphocytes and eosinophils.
  • The observed lesions and clinical history strongly suggest sodium ion intoxication as the etiology.

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Related Experiment Videos

Last Updated: Jun 14, 2026

Use of a Piglet Model for the Study of Anesthetic-induced Developmental Neurotoxicity (AIDN): A Translational Neuroscience Approach
06:38

Use of a Piglet Model for the Study of Anesthetic-induced Developmental Neurotoxicity (AIDN): A Translational Neuroscience Approach

Published on: June 11, 2017

Accessing the Porcine Brain via High-Speed Pneumatic Drill Craniectomy
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Accessing the Porcine Brain via High-Speed Pneumatic Drill Craniectomy

Published on: July 5, 2024

Exposure of the Pig CNS for Histological Analysis: A Manual for Decapitation, Skull Opening, and Brain Removal
08:38

Exposure of the Pig CNS for Histological Analysis: A Manual for Decapitation, Skull Opening, and Brain Removal

Published on: April 13, 2017

Implications:

  • This case highlights the potential for iatrogenic sodium ion intoxication in weaned piglets.
  • Accurate diagnosis relies on correlating clinical signs with detailed histopathological findings.
  • Understanding this condition is crucial for preventing and managing neurological disorders in swine.