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Updated: Jun 14, 2026

Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions
Published on: April 20, 2016
Atopic dermatitis: the role of Langerhans cells in disease pathogenesis
Sandrine Dubrac1, Matthias Schmuth, Susanne Ebner
1Department of Dermatology and Venereology, Innsbruck Medical University, Innsbruck, Austria. Sandrine.Dubrac@i-med.ac.at
Abstract:
The manifestation of atopic dermatitis (AD) results from a complex interaction of environmental factors, skin barrier defects and immunological phenomena. The initial events in AD remain unclear while much progress has been made in identifying the mechanisms leading to the manifestation and maintenance of allergic inflammation. AD pathogenesis can be approached from many different points of view. In this review, we describe findings in mouse models and in humans separately. We focus on recent findings that underscore the importance of Langerhans cells in initial mechanisms of skin inflammation in AD.
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