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Published on: February 7, 2019
An Enantioselective Synthesis of the ABD Tricycle for (-)-Phomactin A Featuring Rawal's Asymmetric Diels-Alder
Ling-Feng You1, Richard P Hsung, Aaron A Bedermann
1Division of Pharmaceutical Sciences and Department of Chemistry, Rennebohm Hall, 777 Highland Avenue, University of Wisconsin, Madison, WI 53705, rhsung@wisc.edu and cole_kevin_p_phd@lilly.com.
Abstract:
An enantioselective synthesis of the ABD-ring of (-)-phomactin A is described here. The sequence features Rawal's asymmetric Diels-Alder cycloaddition. The overall length is significantly reduced from our previous attempt.
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