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Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
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STRIDE--An integrated standards-based translational research informatics platform.

Henry J Lowe1, Todd A Ferris, Penni M Hernandez

  • 1Stanford Center for Clinical Informatics, Stanford University, Stanford CA, USA.

AMIA ... Annual Symposium Proceedings. AMIA Symposium
|March 31, 2010
PubMed
Summary
This summary is machine-generated.

The STRIDE platform integrates clinical data and biospecimen management for translational research. This standards-based informatics system supports over 1.3 million patients at Stanford University.

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Area of Science:

  • Biomedical Informatics
  • Clinical and Translational Science
  • Health Data Management

Background:

  • Clinical and translational research requires robust data management infrastructure.
  • Stanford University developed the STRIDE (Stanford Translational Research Integrated Database Environment) informatics platform.
  • Existing systems may lack integration for diverse research data types.

Purpose of the Study:

  • To describe the architecture and components of the STRIDE informatics platform.
  • To highlight STRIDE's role in supporting clinical and translational research at Stanford.
  • To showcase the use of standardized terminologies within a research data environment.

Main Methods:

  • STRIDE integrates a clinical data warehouse (HL7 RIM-based) with over 1.3 million patient records.
  • It includes an application development framework for research data management.
  • A biospecimen data management system is also a core component.

Main Results:

  • The STRIDE platform is in daily operational use at Stanford University.
  • It effectively integrates diverse data sources, including clinical and biospecimen information.
  • STRIDE utilizes standardized terminologies like SNOMED, RxNorm, ICD, and CPT.

Conclusions:

  • STRIDE provides a comprehensive, standards-based informatics solution for translational research.
  • The platform facilitates data management and supports the goals of Stanford's CTSA Informatics Program.
  • STRIDE's integrated approach enhances the potential for biomedical discovery.