Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chi-square Analysis

Chi-square Analysis

The chi-square test is a statistical hypothesis test. It is used to check whether there is a significant difference between an expected value and an observed value. In the context of genetics, it enables us to either accept or reject a hypothesis, based on how much the observed values deviate from the expected values.
The chi-square test was developed by Pearson in 1990.
The first step of performing a Chi-square analysis is to establish a null hypothesis, which assumes that there is no real...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

Clinical Trials

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...

Drug Discovery: Overview

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...

Prescription, Nonprescription and Orphan Drugs

Prescription, Nonprescription and Orphan Drugs

Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...

Cancer

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Exploring Anti-Aging Literature via <i>ConvexTopics</i> and Large Language Models.

AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science·2026

Same author

Memorization in large language models in medicine prevalence characteristics and implications.

Nature communications·2026

Same author

Systemic Lenvatinib Therapy Combined with Locoregional Chemoembolisation and Hepatic Arterial Infusion Chemotherapy for Advanced Hepatocellular Carcinoma with Main Portal Vein Invasion: A Multicentre Retrospective Case-Control Study.

Cancers·2026

Same author

A Curated Dataset for Question Answering on Laboratory Test Reference Ranges and Interpretation.

Scientific data·2026

Same author

GPR15-guided CD8<sup>+</sup> T regulatory cells control intestinal inflammation.

Nature·2026

Same author

Endovascular revascularization for progressive stroke beyond conventional time windows: safety, efficacy, and predictors of technical failure and restenosis.

Neurosurgical review·2026

Search research articles

Related Experiment Video

Updated: Jun 14, 2026

Comparing Bibliometric Analysis Using PubMed, Scopus, and Web of Science Databases

Comparing Bibliometric Analysis Using PubMed, Scopus, and Web of Science Databases

Published on: October 24, 2019

Finding query suggestions for PubMed.

Zhiyong Lu¹, W John Wilbur, Johanna R McEntyre

¹National Library of Medicine, Bethesda, MD, 20894, USA.

AMIA ... Annual Symposium Proceedings. AMIA Symposium

|March 31, 2010

Summary

This summary is machine-generated.

PubMed users often refine search terms to find relevant documents. A new "Related Queries" feature, based on query log analysis, suggests popular, related searches to improve information retrieval accuracy.

More Related Videos

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

Related Experiment Videos

Last Updated: Jun 14, 2026

Comparing Bibliometric Analysis Using PubMed, Scopus, and Web of Science Databases

Comparing Bibliometric Analysis Using PubMed, Scopus, and Web of Science Databases

Published on: October 24, 2019

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

Area of Science:

Biomedical Informatics
Information Retrieval
User Behavior Analysis

Background:

PubMed users frequently reformulate search queries to meet information needs.
Inefficient searching can lead to prolonged information retrieval times.

Purpose of the Study:

To implement and analyze a novel PubMed feature, "Related Queries," designed to assist users in query reformulation.
To enhance the precision of user information needs through automated query suggestions.

Main Methods:

Developed a query suggestion system leveraging analysis of user query logs.
Focused on identifying popular queries containing the initial user search term.
Integrated the "Related Queries" feature into the PubMed interface.

Main Results:

The "Related Queries" feature was integrated into PubMed in January 2009.
Daily usage analysis indicated consistent adoption, with 6-10% of shown instances utilized.
Clickthrough data suggests the feature is a popular addition for PubMed users.

Conclusions:

The "Related Queries" feature effectively assists PubMed users in refining their search strategies.
Automated query suggestions based on query log analysis improve the user experience and information retrieval efficiency.
The feature has demonstrated rapid user acceptance and integration into common PubMed search practices.